ABSTRACT
Solitary fibrous tumor (SFT) is an uncommon mesenchymal tumor and is classified as an Intermediate (rarely metastasizing) fibroblastic/myofibroblastic tumor (WHO 2013). It occurs as slow growing masses at any location in deep soft tissue, abdomen/pelvis, pleura, the extremities and other sites. We present a case of a 60-year-old woman with a slow growing swelling of the right thigh. On magnetic resonance imaging, a large lobulated, heterogeneously enhancing septated lesion was noted. Wide excision of the lesion showed a well-circumscribed tumor with gray white and mucoid areas. Light microscopic examination showed a circumscribed, partially encapsulated tumor composed of hypercellular areas with intervening hypocellular, hyalinized areas were seen and tumor cells showed diffuse strong CD34 positivity. Based on histopathology and immunohistochemistry (IHC), a final diagnosis of SFT was offered. SFTs belong to a spectrum of neoplasms from benign to malignant which can occur at myriad sites in the body. IHC forms the basis for confirmatory diagnosis. To prevent mislabeling as sarcoma, a high degree of suspicion and radio-histological correlation is warranted to arrive at a conclusive diagnosis.
Subject(s)
Adrenal Gland Neoplasms/diagnosis , Humans , Lung Neoplasms/diagnosis , Male , Middle Aged , Neurilemmoma/diagnosisABSTRACT
A 48 year old female presented with extensive ulceration of the nasal septum of 8 months duration. Investigations confirmed the local nature of the disease. A biopsy revealed large zones of ischemic necrosis and abnormal lymphoid cells invading vessel walls and glandular structures. Florid squamous metaplasia, and pseudoepitheliomatous hyperplasia of mucosal epithelium mimicked squamous cell carcinoma and necrotising sialometaplasia. Immunohistochemistry and insitu hybridization confirmed the diagnosis of an EBV positive, Nasal NK/T cell lymphoma. A Pubmed/Medline search suggests that this is the first documented case from India.